解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::It is now apparent that naïve peripheral T cells are a dynamic population where active processes prevent inappropriate activation while supporting survival. The process of thymic education makes naïve peripheral T cells dependent on interactions with self-MHC for survival. However, as these signals can potentially res...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-008-8017-1
更新日期:2008-01-01 00:00:00
abstract::We have focused our research on understanding the basic biology of and developing novel therapeutic and prophylactic DNA vaccines. We have among others three distinct primary areas of interest which include: 1. Enhancing in vivo delivery and transfection of DNA vaccine vectors 2. Improving DNA vaccine construct immuno...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-008-8076-3
更新日期:2008-01-01 00:00:00
abstract::Genes of the major histocompatibility complex (MHC) are one of the most significant genetic predictors of HIV and SIV disease outcome; however, in no case is MHC genotype alone sufficient to account for this durable HIV/SIV control. Killer immunoglobulin-like receptors (KIRs) interact with MHC molecules and have been ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-007-8010-0
更新日期:2008-01-01 00:00:00
abstract::Epidemiological studies have demonstrated an inverse correlation between prevalence of helminth infections and allergic diseases both associated to Th2 immune responses. On the other hand, such an inverse correlation has also been evidenced between allergies and bacterial infections, associated to Th1 responses. In th...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-007-0058-3
更新日期:2008-01-01 00:00:00
abstract::This review of the events leading to the New Era of Immunology focuses on the important leads provided by the Experiments of Nature. Not only did they provide the path that led to our present knowledge of the ontogeny of the immune system, but also to an entirely new perspective of lymphocytic malignancies. The power ...
journal_title:Immunologic research
pub_type: 历史文章,杂志文章
doi:10.1007/s12026-007-0047-6
更新日期:2007-01-01 00:00:00
abstract::We have recently established new bone marrow transplantation (BMT) methods for the treatment of intractable diseases. The methods include the perfusion method (PM) for the collection of bone marrow cells, and intra-bone marrow (IBM)-BMT for the direct injection of collected whole bone marrow cells into the bone marrow...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-007-0004-4
更新日期:2007-01-01 00:00:00
abstract::Infection of mice with Listeria monocytogenes has led to a puzzling observation: mice deficient in lymphocytes are more resistant during the early innate immune response. This is counterintuitive, because mice deficient in the adaptive immune response are unable to clear the infection and eventually die. This work wil...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1007/s12026-007-0017-z
更新日期:2007-01-01 00:00:00
abstract::Dendritic cells (DC) are the sentinels of the immune system, linking innate with adaptive responses. The functional responses of DC are subject to complex regulation and serve as targets for pathogens. Ca2+-mediated signal transduction pathways serve a central regulatory role in DC responses to diverse antigens, inclu...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-007-0076-1
更新日期:2007-01-01 00:00:00
abstract::Diabetes is a chronic autoimmune disease that affects 4-5% of the world's population. If the present trends continue, diabetes would soon become a major/leading health problem worldwide. Hence there is an urgent need to develop novel approaches for the treatment of diabetes. While transplantation of the pancreas or th...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1007/s12026-007-0070-7
更新日期:2007-01-01 00:00:00
abstract::Gender has long been known to be a contributory factor in the incidence and progression of disorders associated with immune system dysregulation. More recently, evidence has accumulated that gender may also play an important role in infectious disease susceptibility. In general, females generate more robust and potent...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:34:3:177
更新日期:2006-01-01 00:00:00
abstract::Apoptosis, programmed cell death, eliminates injured or harmful cells. It can mediate its response through the actions of death ligands including TRAIL. TRAIL, a member of TNF superfamily, induces apoptosis of transformed cells through the action of death domain receptors DR-4 and DR5. It directly induces apoptosis th...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:35:3:249
更新日期:2006-01-01 00:00:00
abstract::LSP1 is an F-actin bundling cytoskeletal protein expressed in hematopoietic lineage and endothelial cells. We investigated the function of this protein by generating and analyzing an LSP1-deficient mouse strain and in this review we describe our findings together with those of other investigators. The results show a c...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:35:1:65
更新日期:2006-01-01 00:00:00
abstract::The University of Pittsburgh School of Medicine has a long tradition of excellence in immunology research and training. Faculty, students, and postdoctoral fellows walk through hallways that are pictorial reminders of the days when Dr. Jonas Salk worked here to develop the polio vaccine, or when Dr. Niels Jerne chaire...
journal_title:Immunologic research
pub_type: 历史文章,杂志文章
doi:10.1385/IR:36:1:1
更新日期:2006-01-01 00:00:00
abstract::Adenosine suppresses the production of various cytokines/ chemokines and inhibits the cytotoxic activity of murine and human NK cells activated with IL-2 or Ly49D, NKp46-receptor crosslinking, respectively. These effects are mediated by the type A2A adenosine receptor via stimulation of adenylyl cyclase, increased pro...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:36:1:91
更新日期:2006-01-01 00:00:00
abstract::C3d is the final degradation product of the third component of complement (C3). When conjugated to an antigen, C3d enhances immune responses to the fused antigen. Therefore, this molecule has been used as an adjuvant to enhance the immune responses to various foreign and self-proteins. C3d binds to the complement rece...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:36:1:197
更新日期:2006-01-01 00:00:00
abstract::The neonate has an increased susceptibility to infection, in part owing to an inability to produce antibody to thymus-independent antigens such as bacterial polysaccharides (PS). This poor response to PS antigens is likely owing to multiple factors. Neonatal B cells are of an immature phenotype, as evidenced by cell-s...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:31:1:25
更新日期:2005-01-01 00:00:00
abstract::Invariant CD1d-restricted natural killer T (iNKT) cells function during innate and adaptive immune responses. A functional and numerical deficiency of iNKT cells is well documented in both nonobese diabetic (NOD) mice and humans with autoimmune type 1 diabetes (T1D). Restoring the numerical and/or functional deficienc...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:31:3:177
更新日期:2005-01-01 00:00:00
abstract::Although the B-cell antigen receptor (BCR) factors most prominently in the maintenance and differentiation of mature B cells, it is now appreciated that co-receptor molecules can positively or negatively modulate signals through the BCR. Co-receptors are functionally defined as modifiers of BCR engagement and signal t...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:31:2:119
更新日期:2005-01-01 00:00:00
abstract::It is not unusual for antigens and potentially responsive T cells to co-exist in the same organism while these T cells remain silent and do not mount life-threatening immune responses. A rich array of mechanisms has been proposed to explain these observations. T cell silencing is controlled in multiple levels. Initial...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:33:2:135
更新日期:2005-01-01 00:00:00
abstract::The etiology and immunologic states of autoimmune diseases have mainly been discussed without consideration of extrathymic T cells, which exist in the liver, intestine, and excretion glands. Because extrathymic T cells are autoreactive and are often simultaneously activated along with autoantibody-producing B-1 cells,...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:33:1:023
更新日期:2005-01-01 00:00:00
abstract::Mast cells (MC) are important effector cells in allergic disorders. Recently, the role of MC in innate and adaptive immunity is gaining prominence. Nitric oxide is an important signaling molecule and its production in mast cell has been reported widely. However, controversy exists about whether MC produce NO. This rev...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:33:3:223
更新日期:2005-01-01 00:00:00
abstract::Plasmacytoid dendritic cells (pDCs) have been associated with several names and functions over time, reflecting the limited availability of specific markers and their ability to produce large amounts of type I interferons, present antigens, as well as prime disparate T-cell helper responses. Yet, there is increasing e...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:32:1-3:075
更新日期:2005-01-01 00:00:00
abstract::Development can occur by either instructive or stochastic processes. My colleagues and I have studied the contributions of these processes to differentiation of naïve CD4+ T-cells to either a Th1 or Th2 phenotype. Our initial discovery that pathogens in our in vitro priming system led to the development of Th1 cells t...
journal_title:Immunologic research
pub_type: 历史文章,杂志文章,评审
doi:10.1385/IR:32:1-3:193
更新日期:2005-01-01 00:00:00
abstract::In our laboratory we study the mechanisms by which the immune system controls viral infection and by which viruses evade immune control. To study issues at this interface between virology and immunology, we work from the hypothesis that viruses manipulate the immune response as the immune response attempts to eradicat...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:32:1-3:293
更新日期:2005-01-01 00:00:00
abstract::Vaccination represents one of the most efficacious and cost-effective medical interventions. It is the only medical intervention proven to eliminate disease at a global level. Many of the pathogens against which we most require adequate vaccines infect via the highly exposed mucosal surfaces. For this reason the mucos...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:30:1:035
更新日期:2004-01-01 00:00:00
abstract::The intestinal epithelium serves as one of human's primary interfaces with the outside world. This interface is very heavily colonized with bacteria and yet permits absorption of life-sustaining nutrients while protecting the tissues below from microbial onslaught. Although the gut epithelium had been classically thou...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:29:1-3:055
更新日期:2004-01-01 00:00:00
abstract::Eukaryotic cells perceive and respond to microbes, both pathogenic and commensal, by activation of signaling cascades such as the NF-kappaB pathway. Induction of such pathways leads to the upregulation of a program of gene expression that mediates pro-inflammatory and anti-apoptotic effector proteins. This host respon...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:29:1-3:175
更新日期:2004-01-01 00:00:00
abstract::The role of gamma/delta T cells in immunity to bacterial infection and control of inflammation is discussed. Special emphasis is placed on the use of murine models in which various aspects of immune function can be monitored in the absence of gamma/delta T cells. Issues discussed include the response to and control of...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/ir:29:1-3:293
更新日期:2004-01-01 00:00:00
abstract::Herpes simplex virus type 1 infection of the mouse eye results in an impressive inflammatory response culminating in the death of the animal or the establishment of a "latent" infection depending on a number of ill-defined variables that include components of the innate and adaptive immune system. The application of t...
journal_title:Immunologic research
pub_type: 杂志文章
doi:10.1385/IR:30:2:191
更新日期:2004-01-01 00:00:00
abstract::Major histocompatibility (MHC) class II molecules function to present antigenic peptides to CD4 T lymphocytes. The pathways by which these molecules present exogenous antigens have been extensively studied. However by contrast, far less is known about the processing and trafficking of cytosolic antigens, which can als...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:30:3:279
更新日期:2004-01-01 00:00:00
abstract::Anti-CD3 monoclonal antibodies (MAbs) were developed as a way of inducing immune suppression of T cells. More recent studies have indicated that anti-CD3 MAbs can affect immune responses by inducing immune regulation. We recently reported that a single course of treatment with a non-FcR binding anti-CD3 MAb, hOKT3gamm...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:28:2:141
更新日期:2003-01-01 00:00:00
abstract::Allogeneic hematopoietic stem cell transplantation (HSCT) currently provides the only chance of curative therapy for many patients with hematological malignancies. Owing to the excess morbidity and mortality observed in less robust patients, this approach has traditionally been limited to younger patients without sign...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:28:1:1
更新日期:2003-01-01 00:00:00
abstract::Activation-induced cell death (AICD) has been demonstrated in T-cell hybridomas, immature thymocytes, and activated mature T cells. However, the molecular mechanisms of AICD and its physiological role in T-helper-cell differentiation remain uncertain. Recently, we have shown that Th1 and Th2 cells have distinct mechan...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:28:3:285
更新日期:2003-01-01 00:00:00
abstract::Class II MHC molecules present processed peptides from exogenous antigens to CD4+ helper T lymphocytes. In so doing, they are central to immunity, driving both the humoral and cell mediated arms of the immune response. Class II MHC molecules, and the genes encoding them, are expressed primarily in cells of the immune ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:27:1:85
更新日期:2003-01-01 00:00:00
abstract::Anti-double-stranded DNA (dsDNA) B cells persist even in nonautoimmune- prone animals. In this review, we summarize data regarding the activation potential of these cells. Provision of cognate CD4 T cell help to anti-dsDNA B cells in nonautoimmune mice not only drives their maturation and entry into the B cell follicl...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:27:2-3:219
更新日期:2003-01-01 00:00:00
abstract::Building on significant advances in basic tumor immunology over the past decade, current translational efforts to develop novel antitumor T cell therapeutics continue to accelerate. Both passive T cell immunotherapy (e.g., adoptive T cell transfusions) and active immunotherapy (e.g., vaccination) may eventually become...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:27:2-3:341
更新日期:2003-01-01 00:00:00
abstract::Mouse mammary tumor virus (MMTV) is a nonacute transforming retrovirus that causes mammary tumors in susceptible strains of mice. Upon milk-borne transmission, B cells in the gut become infected and subsequently present a virus-encoded superantigen to cognate T cells. These T cells become activated and, in turn, stimu...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:27:2-3:469
更新日期:2003-01-01 00:00:00
abstract::The complement system is well represented in the central nervous system. Glial cells and neurons produce or express all of the activation and regulatory proteins and the C3a/C5a receptors. Inhibition of complement activation is protective in experimental allergic encephalomyelitis, the animal model for multiple sclero...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:26:1-3:007
更新日期:2002-01-01 00:00:00
abstract::Nitric oxide (.NO) is a freely diffusible inter- and intracellular messenger produced by a variety of mammalian cells including vascular endothelium, neurons, smooth muscle cells, macrophages, neutrophils, platelets, and pulmonary epithelium. In smooth muscle cells, platelets, and neutrophils, .NO raises intracellular...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:26:1-3:107
更新日期:2002-01-01 00:00:00
abstract::The indigenous oral microflora and the host are normally in a state of equilibrium; however, the introduction of a pathogen can result in innate and adaptive immune responses that either contribute to the development of the disease or lead to host immunity. The interactions between the microorganisms and the host are ...
journal_title:Immunologic research
pub_type: 杂志文章,评审
doi:10.1385/IR:26:1-3:223
更新日期:2002-01-01 00:00:00